(Actidione®, ββ Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide))
C15H23NO4 • Mr 281.4 • CAS [66-81-9]
Glutarimide antibiotic isolated from
Streptomyces griseus; active
against fungi and yeasts, but not against bacteria. Inhibits eukaryotic
protein synthesis by blocking the translocation step in the elongation cycle
(1,3,8). Blocks translation of mRNA on cytosolic but not on mitochondrial or
chloroplast ribosomes (2,4,6).
Assay (HPLC)
MP
|
min. 90.0 %
98 - 112 °C
|
Actidione = registered trademark of Upjohn.
References:
- McKeehan, W. & Hardesty, B. (1969) Biochem. Biophys. Res. Commun. 36,
625-30
- Neupert, W. et al. (1969) Eur. J. Biochem. 10, 589-91
-
Obrig, T.G. et al. (1971) J. Biol. Chem. 246, 174-81
-
Avadhani, N.G. & Buetow, D.E. (1972) Biochem. J. 128, 353-65
-
Jilek, F. et al. (2000) Animal Reprod. Sci. 63, 101-11
-
Hanten, J.J. & Pierce, S.K. (2001) Biol. Bull. 201, 34-44
-
Jin, S. et al. (2008) Am. J. Physiol. 294, G928-37
-
Schneider-Poetsch, T. et al. (2010) Nat. Chem. Biol. 6, 209-17
Muta. 2, Repr. 1B •
EG-Index: 613-140-00-8 •
GGVSE/ADR: 6.1 I UN2811 •
IATA: 6.1 I UN2811 •
EINECS: 200-636-0 •
WGK: 3L •
HS: 29419000
Storage Temperature: +2 °C to +8 °C
*Please use the inquiry form in the right column.
Package is subject to Dangerous Goods Regulations
Certificates of Analysis
(Lot.-no. - release date)
Material Safety Datasheets
You may find this also interesting:
SERVA InfoMail - Get the latest information
Close window
When subscribing to »SERVA InfoMail« you will receive information about the latest product release, special promotions, new jobs at SERVA and more. This service is, of course, free of charge.
You may remove your name any time from the list of recipients.
Quick Order
Close window
Using the Quick Order field, you can add a product to your shopping cart with just one click. All you have to do: enter the Cat.No. as shown in our catalog in the format xxxxx.yy and click the Go!-Button.
Close window
H300
Deutsch:
Lebensgefahr bei Verschlucken.
English:
Fatal if swallowed.
Français:
Mortel en cas d'ingestion.
Italiano:
Letale se ingerito.
Español:
Mortal en caso de ingestión.
Close window
H341
Deutsch:
Kann vermutlich genetische Defekte verursachen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.
English:
Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.
Français:
Susceptible d'induire des anomalies génétiques <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.
Italiano:
Sospettato di provocare alterazioni genetiche <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.
Español:
Se sospecha que provoca defectos genéticos <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.
Close window
H360D
Deutsch:
Kann das Kind im Mutterleib schädigen.
English:
May damage the unborn child.
Français:
Peut nuire au foetus.
Italiano:
Può nuocere al feto.
Español:
Puede dañar al feto.
Close window
H411
Deutsch:
Giftig für Wasserorganismen, mit langfristiger Wirkung.
English:
Toxic to aquatic life with long lasting effects.
Français:
Toxique pour les organismes aquatiques, entraîne des effets néfastes à long terme.
Italiano:
Tossico per gli organismi acquatici con effetti di lunga durata.
Español:
Tóxico para los organismos acuáticos, con efectos nocivos duraderos.
Close window
P201
Deutsch:
Vor Gebrauch besondere Anweisungen einholen.
English:
Obtain special instructions before use.
Français:
Se procurer les instructions avant utilisation.
Italiano:
Procurarsi istruzioni specifiche prima dell’uso.
Español:
Pedir instrucciones especiales antes del uso.
Close window
P264
Deutsch:
Nach Gebrauch … gründlich waschen.
English:
Wash … thoroughly after handling.
Français:
Se laver … soigneusement après manipulation.
Italiano:
Lavare accuratamente … dopo l’uso.
Español:
Lavarse … concienzudamente tras la manipulación.
Close window
P273
Deutsch:
Freisetzung in die Umwelt vermeiden.
English:
Avoid release to the environment.
Français:
Éviter le rejet dans l’environnement.
Italiano:
Non disperdere nell’ambiente.
Español:
Evitar su liberación al medio ambiente.
Close window
P280
Deutsch:
Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.
English:
Wear protective gloves/protective clothing/eye protection/face protection.
Français:
Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.
Italiano:
Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
Español:
Llevar guantes/prendas/gafas/máscara de protección.
Close window
P301 +P310
Deutsch:
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM oder Arzt anrufen.
English:
IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
Français:
EN CAS D’INGESTION: appeler immédiatement un CENTRE ANTIPOISON ou un médecin.
Italiano:
IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI o un medico
Español:
EN CASO DE INGESTIÓN: Llamar inmediatamente a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico.
Close window
P330
Deutsch:
Mund ausspülen.
English:
Rinse mouth.
Français:
Rincer la bouche.
Italiano:
Sciacquare la bocca.
Español:
Enjuagarse la boca.
