3-Isobutyl-1-methylxanthineresearch grade
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(IBMX, 1-Methyl-3-isobutylxanthine, 3,7-Dihydro-1-methyl-3-(2-methylpropyl)-1H-purine-2,6-dione, 3-Isobutyl-1-methyl-2,6(1H,3H)-purinedione)
C10H14N4O2 • Mr 222.2 • CAS [28822-58-4]
C10H14N4O2 • Mr 222.2 • CAS [28822-58-4]
3-Isobutyl-1-methylxanthine (IBMX) is one of the most potent and nonspecific inhibitors of cyclic nucleotide phosphodiesterases (cAMP- and cGMP-PDE). The increase in cAMP level because of phosphodiesterase inhibition by IBMX activates protein kinase A (PKA), leading to decreased proliferation, increased differentiation, and induction of apoptosis. The inhibitor induces calcium release from intracellular stores in sensory neurons.
IBMX has been used as a culture medium supplement for inducing adipogenic differentiation, for 3T3-L1 preadipocyte differentiation and in the differentiation of mesenchymal stem cells (MSC).
Soluble in ethanol.
|
Assay (NMR) MP |
min. 99.0 % 200 - 203 °C |
References:
- Ashcroft, S.J.H. et al. (1973) FEBS Lett. 20, 263-6
EINECS: 249-259-3 • HS: 29335995
Storage Temperature: +15 °C to +30 °C
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