Aminoglycoside antibiotic, inhibitor of protein biosynthesis. It is active against gram negative and gram positive bacteria. Main component is Kanamycin A. Suitable for prevention of bacterial contamination in cell culture. Used in molecular biology for the selection of resistant bacteria.
Activity: min. 750 U/mg. Easily soluble in water.
Stock solution: 10 mg/ml in H₂O, working solution: 100 µg/ml.


References:

1. Pestka, S. (1971) Annu. Rev. Microbiol. 25, 487-562
2. Mays, D. et al. (1976) J. Chromatogr. 120, 193-202
3. Cox, D. et al. (1977) in: Sammes, P.G. (ed.) Topics in Antibiotic Chemistry, vol. 3, Chichester, Horwood pp. 1-90
4. Lancini, G. & Parenti, F. (1982) Antibiotics: Springer, New York
5. Nakashima, K. et al. (1999) . J. Biol. Chem. 274, 27786-92
6. Vetting, M.W. et al. (2002) Nature Struct. Biol. 9, 653-8
7. Lambert, C. et al. (2003) Environm. Biol. 5, 127-32
8. Kataoka, T. et al. (2004) Plant Physiol. 136, 4198-204

DANGER

Hazard Statements	H360
Precautions	P201 - P202 - P280
Reaction	P308 +P313
Storage	P405

Repr. 1A • WGK: 1 • HS: 29419000
Storage Temperature: +2 °C to +8 °C