Residual endotoxin contamination in advanced biotherapy products is an expensive and often difficult contaminant to control.

Many commercially available protocols are unable to remove endotoxins effectively and are based on non-affinity chromatography methods e.g. ion exchange chromatography, phase separation using Triton X-114 or require time consuming and expensive affinity steps. These costly resins are often supplied as loose resin or packed in slow gravity columns.

The Proteus NoEndo™ spin column kits offer a standardised method for high grade clearance of endotoxin from recombinant proteins, antibodies and viral vectors. These agents are increasingly being designed for therapeutic applications, hence moving them forward efficiently through in vivo studies requires pure preparations of the samples.

The proprietary FlowGo™ technology regulates sample movement through the technologically-advanced affinity resin cartridge, increasing both endotoxin removal and protein recovery. Uniquely, we offer flow rate control for endotoxin removal in a centrifuge.