Chloramphenicolresearch grade, Ph. Eur.

(Chloromycetin, dichloro-N-[β-hydroxy-α(hydroxymethyl)-β-(4-nitrophenyl)ethyl]acetamide, dichloroacetamido-1-(4-nitrophenyl)-1,3-propanediol)
C11H12Cl2N2O5Mr 323.1CAS [56-75-7]

Blocks bacterial protein synthesis by inhibiting the peptidyl transferase activity of the 50S ribosomal subunit. Determination in serum by HPLC (1,2), in meat (3). Molecular basis for chloramphenicol resistance (5,6), effects on plants (7). Used for the selection of clones (8).
50 mg/ml in ethanol yield a clear, very faint yellow solution. For selection of chloramphenicol-resistant Escherichia coli a concentration of 30 - 50 µg/ml are typically used.

Assay (UV)
98.0 - 102.0 %


References:
  1. Wal, J. et al. (1978) J. Chromatogr. 145, 502-6
  2. Danzer, L.A. (1983) Clin. Chem. 29, 856-8
  3. Rüssel, H. (1978) Chromatographia 11, 341-3
  4. Long, K.S. & Porse, B.T. (2003) Nucl. Acids Res. 31,7208-15
  5. Izard, T. (2001) Protein Sci. 10, 1508-13
  6. Schwarz, S. et al. (2004) FEMS Microbiol. Rev. 28, 519-42
  7. Zhu, H. et al. (2011) Int. J. Agric. Biol. 13, 677-82
  8. Munshi, T. et al. (2013) PLOS ONE 8(3):e60143
DANGER
Hazard Statements H350 - H361
Precautions P201 - P202 - P280
Reaction P308 +P313
Storage P405

EINECS: 200-287-4WGK: 3HS: 29414000
Storage Temperature: +15 °C to +30 °C

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H350

Deutsch:

Kann Krebs erzeugen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.

English:

May cause cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Peut provoquer le cancer <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Può provocare il cancro <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Puede provocar cáncer <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.

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H361

Deutsch:

Kann vermutlich die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen <konkrete Wirkung angeben, sofern bekannt> <Expositionsweg angeben, sofern schlüssig belegt ist, dass die Gefahr bei keinem anderen Expositionsweg besteht>

English:

Suspected of damaging fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Susceptible de nuire à la fertilité ou au foetus <indiquer l'effet spécifique s'il est connu> <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Sospettato di nuocere alla fertilità o al feto <indicare l'effetto specifico, se noto><indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Se sospecha que perjudica la fertilidad o daña al feto <indíquese el efecto específico si se conoce><indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía>.

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P201

Deutsch:

Vor Gebrauch besondere Anweisungen einholen.

English:

Obtain special instructions before use.

Français:

Se procurer les instructions avant utilisation.

Italiano:

Procurarsi istruzioni specifiche prima dell’uso.

Español:

Pedir instrucciones especiales antes del uso.

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P202

Deutsch:

Vor Gebrauch sämtliche Sicherheitsratschläge lesen und verstehen.

English:

Do not handle until all safety precautions have been read and understood.

Français:

Ne pas manipuler avant d’avoir lu et compris toutes les précautions de sécurité.

Italiano:

Non manipolare prima di avere letto e compreso tutte le avvertenze.

Español:

No manipular la sustancia antes de haber leído y comprendido todas las instrucciones de seguridad.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.

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P308 +P313

Deutsch:

BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

English:

IF exposed or concerned: Get medical advice/attention.

Français:

EN CAS d’exposition prouvée ou suspectée: consulter un médecin.

Italiano:

IN CASO di esposizione o di possibile esposizione, consultare un medico.

Español:

EN CASO DE exposición manifiesta o presunta: Consultar a un médico.

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P405

Deutsch:

Unter Verschluss aufbewahren.

English:

Store locked up.

Français:

Garder sous clef.

Italiano:

Conservare sotto chiave.

Español:

Guardar bajo llave.