(Polymyxin E sulfate)
C53H104N16O21S2 • Mr 1365.6 • CAS [1264-72-8]
Peptide antibiotic. Mixture of the sulfates of polypeptides produced by
certain strains of Bacillus polymyxa var. colistinus. Acts mainly
against gram negative bacteria. Causes changes in membrane structure resulting
in leakage of small molecules. Soluble in water; stable between pH 2 - 6 at 4
°C. Protect from light.
Assay (HPLC) (sum of polymyxins E1, E2, E3, E1 - I and E1 -7 MOA)
min. 77.0 %
Storm, D.R. et al. (1977) Ann. Rev. Biochem. 46, 723-63
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