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HOME Life Sciences Antibiotics Inhibitors of Protein Synthesis

Cycloheximidecryst. pure

(Actidione®, ββ Dimethyl-2-oxocyclohexyl)-2-hydroxyethyl]-glutarimide))
C15H23NO4 • Mr 281.4 • CAS [66-81-9]

Glutarimide antibiotic isolated from Streptomyces griseus; active against fungi and yeasts, but not against bacteria. Inhibits eukaryotic protein synthesis by blocking the translocation step in the elongation cycle (1,3,8). Blocks translation of mRNA on cytosolic but not on mitochondrial or chloroplast ribosomes (2,4,6).

Assay (HPLC)
MP
min. 90.0 %
98 - 112 °C
Actidione = registered trademark of Upjohn.


References:
  1. McKeehan, W. & Hardesty, B. (1969) Biochem. Biophys. Res. Commun. 36, 625-30
  2. Neupert, W. et al. (1969) Eur. J. Biochem. 10, 589-91
  3. Obrig, T.G. et al. (1971) J. Biol. Chem. 246, 174-81
  4. Avadhani, N.G. & Buetow, D.E. (1972) Biochem. J. 128, 353-65
  5. Jilek, F. et al. (2000) Animal Reprod. Sci. 63, 101-11
  6. Hanten, J.J. & Pierce, S.K. (2001) Biol. Bull. 201, 34-44
  7. Jin, S. et al. (2008) Am. J. Physiol. 294, G928-37
  8. Schneider-Poetsch, T. et al. (2010) Nat. Chem. Biol. 6, 209-17
DANGER
Hazard Statements H300 - H341 - H360D - H411
Precautions P201 - P264 - P273 - P280
Reaction P301 +P310 - P330

Muta. 2, Repr. 1B • EG-Index: 613-140-00-8 • GGVSE/ADR: 6.1 I UN2811 • IATA: 6.1 I UN2811 • EINECS: 200-636-0 • WGK: 3L • HS: 29419000
Storage Temperature: +2 °C to +8 °C

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H300

Deutsch:

Lebensgefahr bei Verschlucken.

English:

Fatal if swallowed.

Français:

Mortel en cas d'ingestion.

Italiano:

Letale se ingerito.

Español:

Mortal en caso de ingestión.

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H341

Deutsch:

Kann vermutlich genetische Defekte verursachen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.

English:

Suspected of causing genetic defects <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Susceptible d'induire des anomalies génétiques <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Sospettato di provocare alterazioni genetiche <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Se sospecha que provoca defectos genéticos <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.

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H360D

Deutsch:

Kann das Kind im Mutterleib schädigen.

English:

May damage the unborn child.

Français:

Peut nuire au foetus.

Italiano:

Può nuocere al feto.

Español:

Puede dañar al feto.

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H411

Deutsch:

Giftig für Wasserorganismen, mit langfristiger Wirkung.

English:

Toxic to aquatic life with long lasting effects.

Français:

Toxique pour les organismes aquatiques, entraîne des effets néfastes à long terme.

Italiano:

Tossico per gli organismi acquatici con effetti di lunga durata.

Español:

Tóxico para los organismos acuáticos, con efectos nocivos duraderos.

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P201

Deutsch:

Vor Gebrauch besondere Anweisungen einholen.

English:

Obtain special instructions before use.

Français:

Se procurer les instructions avant utilisation.

Italiano:

Procurarsi istruzioni specifiche prima dell’uso.

Español:

Pedir instrucciones especiales antes del uso.

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P264

Deutsch:

Nach Gebrauch … gründlich waschen.

English:

Wash … thoroughly after handling.

Français:

Se laver … soigneusement après manipulation.

Italiano:

Lavare accuratamente … dopo l’uso.

Español:

Lavarse … concienzudamente tras la manipulación.

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P273

Deutsch:

Freisetzung in die Umwelt vermeiden.

English:

Avoid release to the environment.

Français:

Éviter le rejet dans l’environnement.

Italiano:

Non disperdere nell’ambiente.

Español:

Evitar su liberación al medio ambiente.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.