Mitomycin Clyophil. research grade
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C15H18N4O5 • Mr 334.3 • CAS [50-07-7]
Potent anti-tumor antibiotic isolated from Streptomyces caespitosus. Belongs to the group of aziridine-containing natural products. Causes intra- and interstrand crosslinks in DNA, which prevent dissociation of the strands, and thus inhibits replication and transcription of DNA. Each vial contains 48 mg sodium chloride as diluent.
References:
- Tomasz, M. et al. (1987) Science 235, 1204-8
- de Klein, A. et al. (2000) Curr. Biol. 10, 479-82
- Martin, T.W. et al. (2002) Structure 10, 933-42
- Mai, Q. et al. (2007) Cell Res. 17, 1008-19
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| WARNING |
| Hazard Statements | H302 - H351 |
| Precautions | P201 - P264 - P280 |
| Reaction | P301 +P312 - P330 |
| Storage | P405 |
Carc. 2 • EINECS: 200-008-6 • WGK: 3L • HS: 29419000
Storage Temperature: +15 °C to +30 °C
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