Actinomycin Dcryst. research grade
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C62H86N12O16 • Mr 1255.5 • CAS [50-76-0]
![](images/imgStruct/190/10710.jpg)
Chromopeptide with antibiotic activity. Contains 2 cyclic peptides bound to the chromophoric phenoxazone ring. Binds specifically to the minor groove of the DNA double helix, and thus prevents it from being a template for RNA synthesis. Antineoplastic agent which inhibits the growth of rapidly dividing cells. Induces apoptosis in cancer cells. Used as a selective agent in cell culture.
References:
- Meienhofer, B. & Atherton, E. (1977) Adv. Appl. Microbiol. 16, 203
- Kleef, J. et al. (2000) Int. J. Cancer 86, 399-407
- Narita, Y. et al. (2000) Cancer Chemother. Pharmacol. 45, 149-56
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DANGER |
Hazard Statements | H300 - H351 - H360 |
Precautions | P201 - P280 |
Reaction | P301 +P310 - P308 +P313 - P330 |
Carc. 2, Repr. 1A • GGVSE/ADR: 6.1 II UN2811 • IATA: 6.1 II UN2811 • EINECS: 200-063-6 • WGK: 3L • HS: 29419000
Storage Temperature: +2 °C to +8 °C