Actinomycin Dcryst. research grade

(Dactinomycin, Actinomycin C1)
C62H86N12O16Mr 1255.5CAS [50-76-0]

Chromopeptide with antibiotic activity. Contains 2 cyclic peptides bound to the chromophoric phenoxazone ring. Binds specifically to the minor groove of the DNA double helix, and thus prevents it from being a template for RNA synthesis. Antineoplastic agent which inhibits the growth of rapidly dividing cells. Induces apoptosis in cancer cells. Used as a selective agent in cell culture.


References:
  1. Meienhofer, B. & Atherton, E. (1977) Adv. Appl. Microbiol. 16, 203
  2. Kleef, J. et al. (2000) Int. J. Cancer 86, 399-407
  3. Narita, Y. et al. (2000) Cancer Chemother. Pharmacol. 45, 149-56
DANGER
Hazard Statements H300 - H351 - H360
Precautions P201 - P280
Reaction P301 +P310 - P308 +P313 - P330

Carc. 2, Repr. 1AGGVSE/ADR: 6.1 II UN2811IATA: 6.1 II UN2811EINECS: 200-063-6WGK: 3LHS: 29419000
Storage Temperature: +2 °C to +8 °C

Cat.No.
Size
EUR
10710.01
5 mg
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H300

Deutsch:

Lebensgefahr bei Verschlucken.

English:

Fatal if swallowed.

Français:

Mortel en cas d'ingestion.

Italiano:

Letale se ingerito.

Español:

Mortal en caso de ingestión.

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H351

Deutsch:

Kann vermutlich Krebs erzeugen <Expositionsweg angeben, sofern schlüssig belegt ist, dass diese Gefahr bei keinem anderen Expositionsweg besteht>.

English:

Suspected of causing cancer <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Susceptible de provoquer le cancer <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Sospettato di provocare il cancro <indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Se sospecha que provoca cáncer <Indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía >.

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H360

Deutsch:

Kann die Fruchtbarkeit beeinträchtigen oder das Kind im Mutterleib schädigen <konkrete Wirkung angeben, sofern bekannt> <Expositionsweg angeben, sofern schlüssig belegt ist, dass die Gefahr bei keinem anderen Expositionsweg besteht>.

English:

May damage fertility or the unborn child <state specific effect if known > <state route of exposure if it is conclusively proven that no other routes of exposure cause the hazard>.

Français:

Peut nuire à la fertilité ou au foetus <indiquer l'effet spécifique s'il est connu> <indiquer la voie d'exposition s'il est formellement prouvé qu'aucune autre voie d'exposition ne conduit au même danger>.

Italiano:

Può nuocere alla fertilità o al feto <indicare l'effetto specifico, se noto><indicare la via di esposizione se è accertato che nessun'altra via di esposizione comporta il medesimo pericolo>.

Español:

Puede perjudicar la fertilidad o dañar al feto <indíquese el efecto específico si se conoce><indíquese la vía de exposición si se ha demostrado concluyentemente que el peligro no se produce por ninguna otra vía>.

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P201

Deutsch:

Vor Gebrauch besondere Anweisungen einholen.

English:

Obtain special instructions before use.

Français:

Se procurer les instructions avant utilisation.

Italiano:

Procurarsi istruzioni specifiche prima dell’uso.

Español:

Pedir instrucciones especiales antes del uso.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.

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P301 +P310

Deutsch:

BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

Français:

EN CAS D’INGESTION: appeler immédiatement un CENTRE ANTIPOISON ou un médecin.

Italiano:

IN CASO DI INGESTIONE: contattare immediatamente un CENTRO ANTIVELENI o un medico

Español:

EN CASO DE INGESTIÓN: Llamar inmediatamente a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico.

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P308 +P313

Deutsch:

BEI Exposition oder falls betroffen: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

English:

IF exposed or concerned: Get medical advice/attention.

Français:

EN CAS d’exposition prouvée ou suspectée: consulter un médecin.

Italiano:

IN CASO di esposizione o di possibile esposizione, consultare un medico.

Español:

EN CASO DE exposición manifiesta o presunta: Consultar a un médico.

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P330

Deutsch:

Mund ausspülen.

English:

Rinse mouth.

Français:

Rincer la bouche.

Italiano:

Sciacquare la bocca.

Español:

Enjuagarse la boca.