Tris-(2-carboxyethyl)phosphine hydrochloride
(TCEP)
C9H16CIO6P
• Mr
286.7
• CAS [51805-45-9]
Water-soluble and odorless reagent for selective and fast reduction of
disulfides. Does not react with other functional groups of proteins.
Unreactive towards many common alkylating reagents, so reductions have been
carried out simultaneously with alkylations. More stable and effective than
DTT. The strength of the phosphorus-oxygen bond makes the reaction
irreversible. Dilute solutions of TCEP (1 mM) react rapidly at room
temperature. Suitable also in mass spectrometry applications.
Assay (titr.)
|
98.0 - 102.0 %
|
References:
-
Kirkley, T.L. (1989) Anal. Biochem. 180, 231-36
-
Burns, J.A. (1991) J. Org. Chem. 56, 2648-50
-
Han, J. a. Han, G.Y. (1994) Anal. Biochem. 220, 5-10
GGVSE/ADR: 8 II UN3261 •
IATA: 8 II UN3261 •
WGK: 1 •
HS: 29420000
Storage Temperature: +2 °C to +8 °C
*Please use the inquiry form in the right column.
Certificates of Analysis
(Lot.-no. - release date)
Material Safety Datasheets
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H314
Deutsch:
Verursacht schwere Verätzungen der Haut und schwere Augenschäden.
English:
Causes severe skin burns and eye damage.
Français:
Provoque des brûlures de la peau et des lésions oculaires graves.
Italiano:
Provoca gravi ustioni cutanee e gravi lesioni oculari.
Español:
Provoca quemaduras graves en la piel y lesiones oculares graves.
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P260
Deutsch:
Staub/Rauch/Gas/Nebel/Dampf/Aerosol nicht einatmen.
English:
Do not breathe dust/fume/gas/mist/vapours/spray.
Français:
Ne pas respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.
Italiano:
Non respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.
Español:
No respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.
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P264
Deutsch:
Nach Gebrauch … gründlich waschen.
English:
Wash … thoroughly after handling.
Français:
Se laver … soigneusement après manipulation.
Italiano:
Lavare accuratamente … dopo l’uso.
Español:
Lavarse … concienzudamente tras la manipulación.
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P280
Deutsch:
Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.
English:
Wear protective gloves/protective clothing/eye protection/face protection.
Français:
Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.
Italiano:
Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
Español:
Llevar guantes/prendas/gafas/máscara de protección.
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P303 +P361 +P353
Deutsch:
BEI KONTAKT MIT DER HAUT (oder dem Haar): Alle beschmutzten, getränkten
Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen/duschen.
English:
IF ON SKIN (or hair): Remove/Take off immediately all contaminated clothing. Rinse skin with water/shower.
Français:
EN CAS DE CONTACT AVEC LA PEAU (ou les cheveux): enlever immédiatement les vêtements contaminés. Rincer la peau à l’eau/se doucher.
Italiano:
IN CASO DI CONTATTO CON LA PELLE (o con i capelli): togliersi di dosso immediatamente tutti gli indumenti contaminati. Sciacquare la pelle/fare una doccia.
Español:
EN CASO DE CONTACTO CON LA PIEL (o el pelo): Quitarse inmediatamente las prendas contaminadas. Aclararse la piel con agua o ducharse.
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P304 +P340
Deutsch:
BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das
Atmen erleichtert.
English:
IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.
Français:
EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.
Italiano:
IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
Español:
EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.
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P305 +P351 +P338
Deutsch:
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen.
Vorhandene Kontaktlinsen nach Möglichkeit entfernen. Weiter spülen.
English:
IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continue rinsing.
Français:
EN CAS DE CONTACT AVEC LES YEUX: rincer avec précaution à l’eau pendant plusieurs minutes. Enlever les lentilles de contact si la victime en porte et si elles peuvent être facilement enlevées. Continuer à rincer
Italiano:
IN CASO DI CONTATTO CON GLI OCCHI: sciacquare accuratamente per parecchi minuti. Togliere le eventuali lenti a contatto se è agevole farlo. Continuare a sciacquare.
Español:
EN CASO DE CONTACTO CON LOS OJOS: Aclarar cuidadosamente con agua durante varios minutos. Quitar las lentes de contacto, si lleva y resulta fácil. Seguir aclarando.
