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G 418 sulfate

(Geneticin®, G418)
C20H40N4O10·2H2SO4 • Mr 692.7 • CAS [108321-42-2]

G 418, or Geneticin, is a aminoglycoside antibiotic from Micromonospora rhodorangea. The antibiotic is used for the selection and maintenance of eukaryotic cells expressing the neomycin resistance gene (neo). G418 blocks polypeptide synthesis by inhibiting the elongation step. It is similar in structure to gentamycin B1 but active against both bacteria and eukaryotes.
Stock solution: 10 - 50 mg/ml in H2O or cell culture medium. The working concentration has to be established for every cell type. Bacteria and algae require 5 μg/ml or less while animal cells may require 300 - 500 μg/ml.

Potency
min. 650 µg/mg
Geneticin = trademark of LTI


References:
  1. Southern, P.J. & Berg, P. (1982) J. Mol. Appl. Genetics 1, 327-41
  2. Bar-Nun, S. et al. (1983) Biochim. Biophys. Acta. 741, 123-7
  3. Hadfield, C. et al. (1990) Curr. Genet. 18, 303-13
  4. Wang, X. et al. (1996) Biotechnol. Bioeng. 49, 45-51
  5. Kunik, T. et al. (2001) PNAS 98, 1871-6
  6. D'Artagnan Villalba, J. et al. (2007) Microbiology 153, 3852-63
  7. Gietz, R.D. & Schiestl, R.H. (2007) Nature Protocols 2, 31-4
DANGER
Hazard Statements H317 - H334
Precautions P261 - P280
Reaction P302 +P352 - P304 +P340 - P333 +P313 - P342 +P311
Storage P501

WGK: 3 • HS: 29419000
Storage Temperature: +15 °C to +30 °C

Cat.No.
Size
EUR
49418.03
1 g
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H317

Deutsch:

Kann allergische Hautreaktionen verursachen.

English:

May cause an allergic skin reaction.

Français:

Peut provoquer une allergie cutanée.

Italiano:

Può provocare una reazione allergica cutanea.

Español:

Puede provocar una reacción alérgica en la piel.

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H334

Deutsch:

Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen.

English:

May cause allergy or asthma symptoms or breathing difficulties if inhaled.

Français:

Peut provoquer des symptômes allergiques ou d'asthme ou des difficultés respiratoires par inhalation.

Italiano:

Può provocare sintomi allergici o asmatici o difficoltà respiratorie se inalato.

Español:

Puede provocar síntomas de alergia o asma o dificultades respiratorias en caso de inhalación.

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P261

Deutsch:

Einatmen von Staub/Rauch/Gas/Nebel/Dampf/Aerosol vermeiden.

English:

Avoid breathing dust/fume/gas/mist/vapours/spray.

Français:

Éviter de respirer les poussières/fumées/gaz/brouillards/vapeurs/aérosols.

Italiano:

Evitare di respirare la polvere/i fumi/i gas/la nebbia/i vapori/gli aerosol.

Español:

Evitar respirar el polvo/el humo/el gas/la niebla/los vapores/el aerosol.

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P280

Deutsch:

Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.

English:

Wear protective gloves/protective clothing/eye protection/face protection.

Français:

Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.

Italiano:

Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.

Español:

Llevar guantes/prendas/gafas/máscara de protección.

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P302 +P352

Deutsch:

BEI KONTAKT MIT DER HAUT: Mit viel Wasser und Seife waschen.

English:

IF ON SKIN: Wash with plenty of soap and water.

Français:

EN CAS DE CONTACT AVEC LA PEAU: laver abondamment à l’eau et au savon.

Italiano:

IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua e sapone.

Español:

EN CASO DE CONTACTO CON LA PIEL: Lavar con agua y jabón abundantes.

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P304 +P340

Deutsch:

BEI EINATMEN: An die frische Luft bringen und in einer Position ruhigstellen, die das Atmen erleichtert.

English:

IF INHALED: Remove victim to fresh air and keep at rest in a position comfortable for breathing.

Français:

EN CAS D’INHALATION: transporter la victime à l’extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.

Italiano:

IN CASO DI INALAZIONE: trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.

Español:

EN CASO DE INHALACIÓN: Transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.

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P333 +P313

Deutsch:

Bei Hautreizung oder -ausschlag: Ärztlichen Rat einholen/ärztliche Hilfe hinzuziehen.

English:

If skin irritation or rash occurs: Get medical advice/attention.

Français:

En cas d’irritation ou d'éruption cutanée: consulter un médecin.

Italiano:

In caso di irritazione o eruzione della pelle: consultare un medico.

Español:

En caso de irritación o erupción cutánea: Consultar a un médico.

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P342 +P311

Deutsch:

Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.

Français:

En cas de symptômes respiratoires: appeler un CENTRE ANTIPOISON ou un médecin.

Italiano:

In caso di sintomi respiratori: contattare un CENTRO ANTIVELENI o un medico.

Español:

En caso de síntomas respiratorios: Llamar a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico.