Lectin from Canavalia ensiformislyophil.
(Concanavalin A from jack bean)
Mr 110 000 • CAS [11028-71-0]
Mitogenic lectin purified from the jack bean, C. ensiformis, that selectively
cross-links cell-surface glycoproteins and affects the initiation of cell
agglutination, mitogenesis, and apoptosis. Concanavalin A (ConA) binds to
D-glucose, D-mannose and sterically related sugars in glycoproteins, and
glycolipids and has been used in affinity chromatography purifications of
various glycoproteins and cellular structures (1).
It has potential
anticancer effects due to mitogenic activity with lymphocytes and cancer cells
(2). When administered, concanavalin A binds to glycoproteins of the cell
membrane, inducing autophagy when it eventually enters the cell.
Simultaneously, it triggers inflammation of tumorous cells, causing an immune
response targeted against those cells. This simultaneous induction of immune
response and autophagy makes it a potentially potent and novel cancer
treatment. It is also used for studies of immune regulation across various
cell types.
References:
- Bessler, W. & Goldstein, I.J. (1973) FEBS Lett. 34, 58-62
- Lin, H. et al. (1975) Cancer Chemother. Rep. 59, 319-26
- Wang, J.L. et al. (1975) J. Biol. Chem. 250, 1490-1502
EINECS: 234-258-2 •
WGK: 1 •
HS: 35040090
Storage Temperature: +2 °C to +8 °C
*Please use the inquiry form in the right column.
Certificates of Analysis
(Lot.-no. - release date)
Material Safety Datasheets
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H317
Deutsch:
Kann allergische Hautreaktionen verursachen.
English:
May cause an allergic skin reaction.
Français:
Peut provoquer une allergie cutanée.
Italiano:
Può provocare una reazione allergica cutanea.
Español:
Puede provocar una reacción alérgica en la piel.
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H334
Deutsch:
Kann bei Einatmen Allergie, asthmaartige Symptome oder Atembeschwerden verursachen.
English:
May cause allergy or asthma symptoms or breathing difficulties if inhaled.
Français:
Peut provoquer des symptômes allergiques ou d'asthme ou des difficultés respiratoires par inhalation.
Italiano:
Può provocare sintomi allergici o asmatici o difficoltà respiratorie se inalato.
Español:
Puede provocar síntomas de alergia o asma o dificultades respiratorias en caso de inhalación.
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P280
Deutsch:
Schutzhandschuhe/Schutzkleidung/Augenschutz/Gesichtsschutz tragen.
English:
Wear protective gloves/protective clothing/eye protection/face protection.
Français:
Porter des gants de protection/des vêtements de protection/un équipement de protection des yeux/du visage.
Italiano:
Indossare guanti/indumenti protettivi/Proteggere gli occhi/il viso.
Español:
Llevar guantes/prendas/gafas/máscara de protección.
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P285
Deutsch:
Bei unzureichender Belüftung Atemschutz tragen.
English:
In case of inadequate ventilation wear respiratory protection.
Français:
Lorsque la ventilation du local est insuffisante, porter un équipement de protection respiratoire.
Italiano:
In caso di ventilazione insufficiente utilizzare un apparecchio respiratorio.
Español:
En caso de ventilación insuficiente, llevar equipo de protección respiratoria.
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P302 +P352
Deutsch:
BEI KONTAKT MIT DER HAUT: Mit viel Wasser und Seife waschen.
English:
IF ON SKIN: Wash with plenty of soap and water.
Français:
EN CAS DE CONTACT AVEC LA PEAU: laver abondamment à l’eau et au savon.
Italiano:
IN CASO DI CONTATTO CON LA PELLE: lavare abbondantemente con acqua e sapone.
Español:
EN CASO DE CONTACTO CON LA PIEL: Lavar con agua y jabón abundantes.
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P304 +P341
Deutsch:
BEI EINATMEN: Bei Atembeschwerden an die frische Luft bringen und in einer Position
ruhigstellen, die das Atmen erleichtert.
English:
IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
Français:
EN CAS D’INHALATION: s'il y a difficulté à respirer, transporter la victime à l'extérieur et la maintenir au repos dans une position où elle peut confortablement respirer.
Italiano:
IN CASO DI INALAZIONE: se la respirazione è difficile, trasportare l'infortunato all’aria aperta e mantenerlo a riposo in posizione che favorisca la respirazione.
Español:
EN CASO DE INHALACIÓN: Si respira con dificultad, transportar a la víctima al exterior y mantenerla en reposo en una posición confortable para respirar.
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P342 +P311
Deutsch:
Bei Symptomen der Atemwege: GIFTINFORMATIONSZENTRUM oder Arzt anrufen.
English:
If experiencing respiratory symptoms: Call a POISON CENTER or doctor/physician.
Français:
En cas de symptômes respiratoires: appeler un CENTRE ANTIPOISON ou un médecin.
Italiano:
In caso di sintomi respiratori: contattare un CENTRO ANTIVELENI o un medico.
Español:
En caso de síntomas respiratorios: Llamar a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico.
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P363
Deutsch:
Kontaminierte Kleidung vor erneutem Tragen waschen.
English:
Wash contaminated clothing before reuse.
Français:
Laver les vêtements contaminés avant réutilisation.
Italiano:
Lavare gli indumenti contaminati prima di indossarli nuovamente
Español:
Lavar las prendas contaminadas antes de volver a usarlas.
