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(Synthetic drop-in substitute for digitonin, Glyco-diosgenin)
C56H92O25 • Mr 1165,31 • CAS [1402423-29-3]
C56H92O25 • Mr 1165,31 • CAS [1402423-29-3]
CMC (H2O, 25 °C) ca. 18 µM
Synthetic, non-toxic, cost-effective substitute for digitonin ideal for the
solubilization, purification, and Cryo-EM studies of membrane proteins.
It
contains a steroid-based hydrophobic group linked to a di-maltose head group.
The
molecular weight is similar to digitonin, but CMC is much smaller. No
batch-to-batch variability due to synthetic nature. Contains no harmful toxic
byproducts typically found in digitonin, such as digitoxin, digoxin, and other
cardiac and steroidal glycosides.
Because it is a milder detergent compared
to DDM, it is effective in maintaining membrane proteins in a functional state.
|
Purity (HPLC)
Solubility in H2O (20 °C) |
≥ 98 % ≥ 10 % |
References:
- Thomas, J. A. & Tate, C. G. (2014) J. Mol. Biol. 426(24), 4139-4154
 |
| WARNING |
| Hazard Statements | H335 |
| Precautions | P261 - P271 |
| Reaction | P304 +P340 - P312 |
| Storage | P405 |
HS: 34029010
