Polymyxin-B·sulfateresearch grade, Ph. Eur.

(Aerosporin)
CAS [1405-20-5]

Mixture of the sulfates of polypeptides produced by the growth of certain strains of Bacillus polymyxa, the main component being Polymyxin B1.
Assay (HPLC): sum of Polymyxins B1, B2, B3 and B1-I min. 80 %; Polymyxin B3 max. 6 %; Polymyxin B1-I max. 15 %
Peptide antibiotic that mainly acts against gram negative bacteria. Causes changes in membrane structure resulting in leakage of small molecules. Used in cell culture media against the contamination of bacteria or in other media for suppression of pathogenic germs (2,3). Inhibitor of the mitogenic response to lipopolysaccharide (4).


References:
  1. Storm, D.R. et al. (1977) Ann. Rev. Biochem. 46, 723-63
  2. Kwak, B. et al. (2000) Nature Medicine 6, 1399-1402
  3. Alvarez-Dolado, M. et al. (2003) Nature 425, 968-73
  4. Jacobs, D.M. & Morrison, D.C. (1977) J. Immunol. 118, 21-7
  5. Asea, A. et al. (2000) Nature Medicine 6, 435-42
WARNING
Hazard Statements H302
Precautions P264
Reaction P301 +P312 - P330
Storage P501

HS: 38210000
Storage Temperature: +2 °C to +8 °C

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H302

Deutsch:

Gesundheitsschädlich bei Verschlucken.

English:

Harmful if swallowed.

Français:

Nocif en cas d'ingestion.

Italiano:

Nocivo se ingerito.

Español:

Nocivo en caso de ingestión.

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P264

Deutsch:

Nach Gebrauch … gründlich waschen.

English:

Wash … thoroughly after handling.

Français:

Se laver … soigneusement après manipulation.

Italiano:

Lavare accuratamente … dopo l’uso.

Español:

Lavarse … concienzudamente tras la manipulación.

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P301 +P312

Deutsch:

BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM oder Arzt anrufen.

English:

IF SWALLOWED: Call a POISON CENTER or doctor/physician if you feel unwell.

Français:

EN CAS D’INGESTION: appeler un CENTRE ANTIPOISON ou un médecin en cas de malaise.

Italiano:

IN CASO DI INGESTIONE accompagnata da malessere: contattare un CENTRO ANTIVELENI o un medico.

Español:

EN CASO DE INGESTIÓN: Llamar a un CENTRO DE INFORMACIÓN TOXICOLÓGICA o a un médico si se encuentra mal.

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P330

Deutsch:

Mund ausspülen.

English:

Rinse mouth.

Français:

Rincer la bouche.

Italiano:

Sciacquare la bocca.

Español:

Enjuagarse la boca.